R packages by bips-hb

neuralnet - Training of Neural Networks

Training of neural networks using backpropagation, resilient backpropagation with (Riedmiller, 1994) or without weight backtracking (Riedmiller and Braun, 1993) or the modified globally convergent version by Anastasiadis et al. (2005). The package allows flexible settings through custom-choice of error and activation function. Furthermore, the calculation of generalized weights (Intrator O & Intrator N, 1993) is implemented.

Last updated 4 years ago

10.93 score 32 stars 37 dependents 2.9k scripts 17k downloads

innsight - Get the Insights of Your Neural Network

Interpretation methods for analyzing the behavior and individual predictions of modern neural networks in a three-step procedure: Converting the model, running the interpretation method, and visualizing the results. Implemented methods are, e.g., 'Connection Weights' described by Olden et al. (2004) <doi:10.1016/j.ecolmodel.2004.03.013>, layer-wise relevance propagation ('LRP') described by Bach et al. (2015) <doi:10.1371/journal.pone.0130140>, deep learning important features ('DeepLIFT') described by Shrikumar et al. (2017) <doi:10.48550/arXiv.1704.02685> and gradient-based methods like 'SmoothGrad' described by Smilkov et al. (2017) <doi:10.48550/arXiv.1706.03825>, 'Gradient x Input' or 'Vanilla Gradient'. Details can be found in the accompanying scientific paper: Koenen & Wright (2024, Journal of Statistical Software, <doi:10.18637/jss.v111.i08>).

Last updated 2 months ago

6.95 score 27 stars 55 scripts 797 downloads

arf - Adversarial Random Forests

Adversarial random forests (ARFs) recursively partition data into fully factorized leaves, where features are jointly independent. The procedure is iterative, with alternating rounds of generation and discrimination. Data becomes increasingly realistic at each round, until original and synthetic samples can no longer be reliably distinguished. This is useful for several unsupervised learning tasks, such as density estimation and data synthesis. Methods for both are implemented in this package. ARFs naturally handle unstructured data with mixed continuous and categorical covariates. They inherit many of the benefits of random forests, including speed, flexibility, and solid performance with default parameters. For details, see Watson et al. (2022) <arXiv:2205.09435>.

Last updated 2 months ago

6.43 score 13 stars 13 scripts 314 downloads

cpi - Conditional Predictive Impact

A general test for conditional independence in supervised learning algorithms as proposed by Watson & Wright (2021) <doi:10.1007/s10994-021-06030-6>. Implements a conditional variable importance measure which can be applied to any supervised learning algorithm and loss function. Provides statistical inference procedures without parametric assumptions and applies equally well to continuous and categorical predictors and outcomes.

Last updated 2 months ago

5.42 score 11 stars 24 scripts 248 downloads

blockForest - Block Forests: Random Forests for Blocks of Clinical and Omics Covariate Data

A random forest variant 'block forest' ('BlockForest') tailored to the prediction of binary, survival and continuous outcomes using block-structured covariate data, for example, clinical covariates plus measurements of a certain omics data type or multi-omics data, that is, data for which measurements of different types of omics data and/or clinical data for each patient exist. Examples of different omics data types include gene expression measurements, mutation data and copy number variation measurements. Block forest are presented in Hornung & Wright (2019). The package includes four other random forest variants for multi-omics data: 'RandomBlock', 'BlockVarSel', 'VarProb', and 'SplitWeights'. These were also considered in Hornung & Wright (2019), but performed worse than block forest in their comparison study based on 20 real multi-omics data sets. Therefore, we recommend to use block forest ('BlockForest') in applications. The other random forest variants can, however, be consulted for academic purposes, for example, in the context of further methodological developments. Reference: Hornung, R. & Wright, M. N. (2019) Block Forests: random forests for blocks of clinical and omics covariate data. BMC Bioinformatics 20:358. <doi:10.1186/s12859-019-2942-y>.

Last updated 2 years ago

cpp

4.52 score 7 stars 47 scripts 271 downloads

micd - Multiple Imputation in Causal Graph Discovery

Modified functions of the package 'pcalg' and some additional functions to run the PC and the FCI (Fast Causal Inference) algorithm for constraint-based causal discovery in incomplete and multiply imputed datasets. Foraita R, Friemel J, Günther K, Behrens T, Bullerdiek J, Nimzyk R, Ahrens W, Didelez V (2020) <doi:10.1111/rssa.12565>; Andrews RM, Foraita R, Didelez V, Witte J (2021) <arXiv:2108.13395>; Witte J, Foraita R, Didelez V (2022) <doi:10.1002/sim.9535>.

Last updated 2 years ago

causal-discoverygraphical-modelsmultiple-imputation

3.70 score 5 stars 20 scripts 219 downloads

tpc - Tiered PC Algorithm

Constraint-based causal discovery using the PC algorithm while accounting for a partial node ordering, for example a partial temporal ordering when the data were collected in different waves of a cohort study. Andrews RM, Foraita R, Didelez V, Witte J (2021) <arXiv:2108.13395> provide a guide how to use tpc to analyse cohort data.

Last updated 2 years ago

causal-discoverycohort-analysisgraphical-models

3.60 score 5 stars 16 scripts 170 downloads

pvm - PharmacoVigilance Methods

A collection of methods used in the field of pharmacovigilance for the dectection of 'interesting' drug-adverse event pairs from spontaneous reporting data.

Last updated 3 months ago

pharmacovigilancecpp

3.30 score 25 stars 16 scripts